This Mandala features a phrase from the Medicine King Chapter. At the top, Nichiren {I assume} wrote "byo soku shometsu" and "furo, fushi." That means something like "Sickness Instantly Obliterated" and "Never Aging, Never Dying."
I have no doubt that we can overcome illness and prolong our lives. However, the statement goes beyond that. It says that we will be instantly cured of our human afflictions; and we shall never know old age or death. Maybe that is partly symbolic; but I think it is literal on another level. As we get past the pathetic ego, and awaken to who we really are; at that non-time, we shall be something or no thing that is never sick, never ages, and never dies.
Gohonzon # 049 in the 日蓮聖人御本尊集 {Nichiren Shonin Gohonzon Catalog}.
"This sutra provides good medicine for the ills of the people of Jambudvipa. If a person who has an illness is able to hear this sutra, then his illness will be wiped out and he will know neither old age or death." from the Yakuo [Medicine King] Chapter of the LS. {Watson translation}

If she thinks someone is a threat, she bares her teeth, snarls, and looks ferocious. To someone on the wrong end of that snarl, she looks like a demon dog from heck. To someone she is protecting, the dog is like a guardian angel. In the Dharani Chapter, Kishimojin and her Ten Rasetsunyo daughters fiercely utter, "If there are those who fail to heed our spells and trouble and disrupt the preachers of the Dharma, their heads will split into seven pieces like the branches of the arjaka [basil shrub]."
"And at that moment Vajrapani the Yaksha, holding up a huge iron club, flaming, ablaze and glowing, up in the sky just above Ambattha was thinking, "If this young man does not answer a proper question put to him by the Blessed Lord by the third time of asking, I'll split his head into seven pieces!" The Lord saw Vajrapani, and so did Ambattha. And at the sight, Ambattha was terrified and unnerved, his hairs stood on end, and he sought protection, shelter, and safety from the Lord. Crouching down close to the Lord, he said, "What did the Reverend Gotama say? May the Reverend Gotama repeat what he said!"
Note that there is a whole Chapter of the Lotus Sutra devoted to the transformations of Kanzeon. He or she appears in various forms to meet the needs of those who summon up the heart of real karuna-compassion. The Kanzeon Chapter examples of people who find themselves in dire straits; they are attacked on the road by bandits, shackled in chains, about to be executed, victimized by spells, and so on. In each case, if the person calls on Kwan Yin, they are saved. The bandits freeze in their tracks and become kind hearted. The chains are loosed. The executioner's sword shatters into seven pieces. The curses are returned to the sender. My take is that is these examples dramatize or illustrate the incredible redeeming, conciliatory, and healing power of Maha Karuna 大悲 {daihi; dabei} or Great Compassion. I suspect that the idea is, when we confront enmity, malevolence, or cruelty; whether in ourselves or others, to channel Kwan Yin (who represents the merit of Great Compassion) within our heart 心.
Like Kishimojin, Tara plays a protective role, and has both fierce or wrathful and mild or benevolent forms. There are many legends about Tara's origin. According to one, she started out in Hinduism as a blood sucking demon; but something happened to arouse her heart of female protective compassion. After that she become a benevolent goddess. This parallels Hariti's {Kishimojin} transformation from a Raksha demon; who fed human children to her own Rakshasha children, to a benevolent angelic being that protects children of all species. "Green Tara, who embodies active female wisdom, is sometimes called the 'Mother of All Buddhas'. She manifests in many emanations; both peaceful and wrathful in form. The merits acquired from the Green Tara meditation are quick thinking, practical wisdom, skillful compassion, generosity, magical powers, fearlessness, spontaneity, and general protective-ness." ~~ Green Tara Mantra
Note also that Kishimojin [鬼子母神] and the Ten Demon Daughters [十羅刹女] were preta or hungry ghosts 餓鬼 {gaki} who drained people's virya or vitality, before the Buddha saved them. Now, they are a kind of benevolent angels who use their negative energy to protect travellers 行者 {gyoja}or votaries of the Lotus Sutra [法華経 行者], They break the heads of arrogant people, who plague or vex the votaries, into seven pieces. My take is that means the negative energies can be converted to positive energies; that the creepy angst of dukkha can be changed into a stable, mellow and blissful joy or sukha right here and now. We do not need to die and be reborn in the Gokuraku or Sukhavati heaven.
to be continued ...
Mandala Number # 050 in the 日蓮聖人御本尊集 {Nichiren Shonin Gohonzon Catalog}. It is mapped here: 日蓮聖人 大漫荼羅 050
As on many of Nichiren's Mandala Honzons, there is a long phrase on the lower left side, or your right when facing the mandala. On this one, it reads: 
仏滅度後度 Butsumetsu do ; Buddha's death
度
後 go; duration after
二千 ni sen; 2000
二百 ni hyaku 200
三十 san ju = 30
余年 yo nen = more years
之間 no aida = this interval
提 ichi = all of
一閻浮 Enbu dai = a transliteration of Jambhu dvipa; this World. Jambu is a Rose Apple. The Jambu tree bears flowers that resemble roses, and a sweet, watery fruit that looks like a small apple. Dvipa means continent or island. In Buddhist cosmology, Jambudvipa is the world of humans, our planet.
之内 no uchi = this between;
未曽有 mi zo u = not yet, never existed; unprecedented; unheard of;
大漫荼羅 dai man da ra = mahamandala = great mandala
也 nari = also, too, a strong affirmation.
More than 2,230 years have transpired, since the Buddha's death. Moreover, In between then and now, this Daimandara was unheard of in this world.
Originally Authored On 2006-09-23 06:48:23
Updated and Reopened on April 04 2009. I have a few more changes to make in this entry.
Nichiren and Nakayama Hokkekyo-ji
Life and legends of Nichiren
At Boso Hanto 1264-1267
The Kishimojin Hall
According to a legend, Nichiren is said to have carved a statue of Kishimojin, shortly after the Komatsubara attack. This is kept in the Kishimojin-do at Nakayama Hokkekyoji. I am not sure which form this is, as I now have conflicting information. I believe it is the fierce, demon troll form.
See: On the Kishimojin Statues
Statues, Drawings, & Paintings of Nichiren
Nakayama Hokekyo-ji Temple is home to two well known statues of Nichiren; a cast standing outdoor statue; and a carved wooden seated altar statue. The seated Nichiren is holding an extended scroll of the Lotus Sutra and is enshrined in the Founder's Hall. IIRC, both date to the Edo Era.
The Reverend Zuiun Matsuda, a Nichiren Shu Minister & owner/sculptor of Buddhist Images World, has carved a replica of the Founder's Hall Statue: Cypresswood Saint Nichiren, Hokekyo-ji Temple in Nakayama model Nichiren statue (This Nichiren image is modeled after the Nichiren statue in Hokekyoji temple with the extended scroll of sutra). Link Here
The nearby Nakayama Joko-in 中山 淨光院, houses the 13th Century Mizukagami Portrait.
Another nearby Temple, Nichihonji, owns a 15th C seated statue.
Shaka Great Buddha Statue at Nakayama Hokkekyo-ji
This is not the same as the Amida Great Buddha of Kamakura or the Dainichi Great Buddha of Nara. Despite the revisionist claims of Taisekiji and SGI, Nichiren actually encouraged his followers to carve statues of Shakyamuni. The statues are concecrated as either the "recompense body" {sambhoga-kaya or hojin} of the Eternal Shakyamuni described in the Lotus Sutra; or as "Shakyamuni Buddha, the lord of teachings, eternally endowed with the three bodies."
The "recompense body" {sambhoga-kaya or hojin} of the Eternal Shakyamuni, aka the Celestial or Ascended Shakyamuni Buddha, bridges the gap between the Transformational Body {Nirmana Kaya; Ojin} aka the historical Gotama/Shakyamuni; and the uncreated, impersonal Law Body {Dharma Kaya, Hoshin}. In one sense, the Celestial or Ascended Shakyamuni Buddha embodies the idealized personal or subjective qualities of the historical Gotama/Shakyamuni, such as compassion and wisdom. On another level, he is the personification of the impersonal or objective Dharma.
The Shakyamuni Great Buddha of Nakayama was cast in 1819. This Shaka Daibutsu is seated in the Padmasana {Blue Lotus Posture} with his hands in the Samadhi-Dhyana Mudra {Meditative Absorption Gesture}.
Nichiren's Gohonzon for Practicing Kanjin
There are no Nichiren Mandalas at Kakyama Hokkekyo-ji at present. There is a story that there were 9 there at one time; but these were stolen some 100 years ago. This mandala, below, appeared at an auction with an asking price of 800,000 US dollars:

The auction advertisement read: "Nichiren Daishonin while doing shugyo [ascetic training] at Nakayama Hokkeji wrote this real Gomandala and the same temple has preserved it."
We know that Nichiren was at Nakayama for a few months, 1260-1261; this was his "Flight from the Matsubagayatsu Persecution". He returned again in 1264 (Prolonged his Mother's life, "Komatsubara Persecution") and remained until 1267. It is said that he taught the ascetic training during the latter stay.
Toki Jonin founded the Hokke-do in 1260, which he later expanded and renamed Hokke-ji. A short time later Ohta Jomyo founded what would become Honmyoji. In 1545 the Hokkeji and the Honmyoji Temples were united as the Nakayama Hokekyoji Temple.
There appear to be at least two {2} original Nichiren Mandala Gohonzon{s} kept at 中山 法宣院 Nakayama Hosen-in; which is located near Nakayama Hokkekyo-ji:
Mandala # 047. LBIS Link. Dated March 16, 1278 (Koan 1). This appears to bear personal side notes. Coffehouse Gohonzon Shu Link. Mandala inscribed by Nichiren, very abbreviated style.
Mandala #064. LBIS Link. Dated June 1279 (Koan 2). Coffehouse Gohonzon Shu Link. 'Later' {Thick Brush Stroke; Emanation Buddhas not present} Great Mandala Gohonzon inscribed by Nichiren, formal style.
In addition, 中山 淨光院 Nakayama Joko-in, , houses at least one {1} original Nichiren Mandala Gohonzon:
Mandala #059. LBIS Link. Dated February 2, 1279. This is one of six {6} authenticated and published Nichiren Mandalas that appear to bear the "Gain & Loss Inscriptions." Unlike on the Taisekiji transcriptions, these inscriptions are NOT in a prominent position. They are NOT located in the top row, on either side of the Daimoku, outside of {flanking}, the two Buddhas and four Bodhisattvas. They appear to be side inscriptions or personal notes. Coffehouse Gohonzon Shu Link.. 'Middle' {Fine Brush Stroke; Emanation Buddhas not present} Great Mandala Gohonzon inscribed by Nichiren, formal style.
Kyoto Honpo-ji: Nisshin of the Nakayama Lineage founded Kyoto Honpo-ji circa 1429 . There are at least four {4} original Nichiren Mandala Gohonzon{s] kept there:
Mandala #088. LBIS Link. Coffehouse Gohonzon Shu Link. 'Later' {Thick Brush Stroke; Emanation Buddhas not present} Great Mandala Gohonzon inscribed by Nichiren, formal style.
Mandala #095. LBIS Link. Coffehouse Gohonzon Shu Link. 'Later' {Thick Brush Stroke} Mandala Gohonzon inscribed by Nichiren, abbreviated style.
Mandala #104. LBIS Link. Coffehouse Gohonzon Shu Link. 'Later' {Thick Brush Stroke; Emanation Buddhas not present} Great Mandala Gohonzon inscribed by Nichiren, formal style.
Mandala #113. LBIS Link. Coffehouse Gohonzon Shu Link. 'Later' {Thick Brush Stroke} Mandala Gohonzon inscribed by Nichiren, abbreviated style.

Sakai Myokoku-ji, [Link Myokoku-ji Temple's Cycad] is a Nakayama Lineage Temple located at Sakai City in Osaka Prefecture. It was founded in 1562.
This temple is associated with the "Sakai-jiken"(contention) which occurred in 1868 (a French soldier was killed by soldiers of the Tosa clan). As punishment, the eleven clansmen involved in the incident were forced to commit harakiri in this temple. The incident was the theme of the novel "Sakai jiken," written by Mori Ogai, a great literary figure of the Meiji Period (1868-1912).
Sakai Myokoku-ji is home to at least three {3} original Nichiren Mandala Gohonzon{s]:
Mandala #020. LBIS Link. Dated April 1275 (Bunei 12)Coffehouse Gohonzon Shu Link. Early Mandala Gohonzon inscribed by Nichiren, formal style.
Mandala #071. LBIS Link. Coffehouse Gohonzon Shu Link. 'Later' {Thick Brush Stroke; Emanation Buddhas not present} Great Mandala Gohonzon inscribed by Nichiren, formal style.
Mandala #121. LBIS Link. Coffehouse Gohonzon Shu Link. 'Later' {Thick Brush Stroke} Mandala Gohonzon inscribed by Nichiren, abbreviated style.

Nisshuku Shonin, a cleric from Nakayama Hokkekyo-ji, founded Kyoto Chomyo-ji Temple in 1673. Kyoto Chomyo-ji [Link] houses two {2} original Nichiren Mandala Gohonzon{s]:
Mandala #007. LBIS Link. No date. Coffehouse Gohonzon Shu Link. Early Mandala inscribed by Nichiren, very abbreviated style.
Mandala #050.LBIS Link. Dated July 5, 1278 (Koan 1). Coffehouse Gohonzon Shu Link. 'Middle' {Fine Brush Stroke; Emanation Buddhas not present} Great Mandala Gohonzon inscribed by Nichiren, formal style.
I am not sure if Tenjusan Chomyo-ji is the same temple as Kyoto Chomyo-ji. I think Tenjusan Chomyo-j might be in Chiba Prefecture.
Life and legends of Nichiren At Boso Hanto 1264-1267
Soseino Amulet of 1264
Nichiren at Hanabusa 1264
Nichiren and Nakayama Hokkekyo-ji
Nakayama Hokkekyo-ji Treasures